Diisopropylethylamine → HCID 71668098, compound

Participants

Reaction Steps

A solution of 7-hydroxy-3,8-dimethyl-2-(piperidin-4-yl)-4H-chromen-4-one (68 mg, 0.25 mmol) obtained in Example 7-2, 3,3,3-trifluoropropionic acid (33 μL, 0.30 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (192 mg, 1.00 mmol), and diisopropylethylamine (86 μL, 0.50 mmol) in dimethylformamide (1.5 mL) was stirred at room temperature for 4 hours. The reaction solution was concentrated, and water was added to the obtained residue, followed by extraction with ethyl acetate. The organic layer was dried over sodium sulfate. The desiccant was filtered off, and then the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (chloroform/methanol=100/0→95/5) to obtain 13 mg of the title compound (yield: 13%).

Provenance & Evidence