Sodium Hydroxide → HCID 117701628, compound

Participants

Reaction Conditions

Reaction Steps

A 1 N aqueous sodium hydroxide solution (4 mL) was added to a solution of methyl 4-{[4-(7-hydroxy-3,8-dimethyl-4-oxo-4H-chromen-2-yl)piperidin-1-yl]methyl}benzoate (140 mg, 0.33 mmol) obtained in Example 23-1 in methanol (4 mL), and the mixture was heated with stirring at a bath temperature of 50° C. for 4 hours. Methanol in the reaction solution was distilled off under reduced pressure. Then, a 1 N aqueous hydrochloric acid solution (4 mL) and water (10 mL) were added to the residue, and insoluble matter was collected by filtration to obtain 125 mg of the title compound (yield: 89%).

Provenance & Evidence