Tributylstannane → HCID 117701723, compound

Participants

Reaction Steps

Tri-n-butyltin hydride (104 μL, 0.39 mmol) and a catalytic amount of azobisisobutyronitrile were added to a solution of benzyl 4-[7-(benzyloxy)-3-methyl-4-oxo-8-{2,2,2-trifluoro-1-[(1H-imidazol-1-ylcarbonothioyl)oxy]ethyl}-4H-chromen-2-yl]piperidine-1-carboxylate (135 mg, 0.20 mmol) obtained in Example 36-3 in tetrahydrofuran (1.5 mL), and the mixture was heated to reflux for 1 hour. The reaction solution was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (n-hexane/ethyl acetate=80/20→40/60) to obtain 105 mg of the title compound (yield: 95%).

Provenance & Evidence