Water → HCID 117701507, compound

Participants

Reaction Steps

Potassium carbonate (995 mg, 7.20 mmol) and methyl iodide (1.50 mL, 24.0 mmol) were added to a solution of 4-hydroxy-7-(methoxymethoxy)-3,8-dimethyl-2H-chromene-2-thione (1.60 g, 6.00 mmol) obtained in Example 37-1 in acetone (16 mL), and the mixture was refluxed for 45 minutes. After cooling to room temperature, water (15 mL) was added to the reaction solution, followed by extraction with ethyl acetate. The obtained residue was purified by silica gel column chromatography (n-hexane/ethyl acetate=95/5→60/40) to obtain 1.34 g of the title compound (yield: 80%).

Provenance & Evidence