Triethylamine → HCID 117701583, compound

Participants

Reaction Steps

1-Acetylpiperazine (220 mg, 1.70 mmol) and triethylamine (1 mL) were added to a solution of 7-(methoxymethoxy)-3,8-dimethyl-2-(methylsulfonyl)-4H-chromen-4-one (171 mg, 0.55 mmol) obtained in Example 37-3 in dimethyl sulfoxide (5 mL), and the mixture was stirred for 5 hours under cooling with ice. Ethyl acetate was added to the reaction solution. The organic layer was washed with water and then dried over anhydrous sodium sulfate, and then the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (chloroform/methanol=97/3→93/7) to obtain 60 mg of the title compound (yield: 30%), which was used directly in the next reaction.

Provenance & Evidence