Ethanesulfonic acid → HCID 131734372, compound

Participants

Reaction Conditions

Reaction Steps

Vemurafenib free-base (0.5 g) was suspended in 10 mL acetone at 30-35° C. Ethanesulfonic acid (0.11 g) was added at 30-35° C. and the mixture was cooled to 0-5° C. within 30 minutes. The resulting precipitate was isolated by filtration and washed with acetone (2 mL) The product was dried under reduced pressure (20 mbar) at room temperature to yield 0.57 g of Vemurafenib esylate as a white powder.

Provenance & Evidence