1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) → HCID 117677846, compound

Participants

Reaction Steps

A mixture of Compound 10 (0.10 g, 0.225 mmol), 4-bromo-2,6-dimethylpyridine (0.108 g, 0.676 mmol), Xantphos (0.078 g, 0.135 mmol), sodium phenoxide (0.044 g, 0.383 mmol) and Pd2(dba)3 (0.041 g, 0.045 mmol) in dioxane (3.0 ml) were degassed and heated under nitrogen to reflux for 18 h. The reaction was cooled to room temperature and concentrated. The residue was then purified by column chromatrography on silica gel (MeOH/DCM) to give the title compound. LCMS 1.86 min, 549 (M+H)

Provenance & Evidence