Morpholine → (R)-Tert-butyl 3-(6-methoxy-2-morpholinopyrimidin-4-ylamino)piperidine-1-carboxylate

Participants

Reaction Conditions

Reaction Steps

Compound 19 (150 mg, 0.405 mmol) was dissolved in acetonitrile (2 mL) and morpholine (0.282 mL, 3.24 mmol) was added, The solution was sealed and heated to 100° C. for 18 h. The solution was concentrated and the residue was purified by column chromatography on silica gel, eluting with EtOAc/hexane to give the title compound as a colorless oil. 1H NMR (CDCl3) δ 5.13 (s, 1H), 4.52-4.51 (m, 1H), 3.82 (s, 3H), 3.72 (s, 8H), 3.62-3.59 (m, 2H), 3.14-3.10 (m, 2H), 1.94 (m, 1H), 1.72-1.70 (m, 1H), 1.55-1.53 (m, 2H), 1.43 (s, 9H); LCMS 2.02 min, 394 (M+H).

Provenance & Evidence