Morpholine → HCID 89545209, compound

Participants

Reaction Conditions

Reaction Steps

To (S)-tert-butyl 3-((5-fluoro-6′-methoxy-2′-(methylsulfonyl)-[2,5′-bipyrimidin]-4′-yl)amino)piperidine-1-carboxylate (0.05 g, 0.104 mmol) in MeCN (3.5 mL) was added morpholine (0.027 ml, 0.311 mmol) in a pressure tube. The reaction was heated to 100° C. for 18 h. Upon completion of the reaction, the solvent was removed and reaction was purified via column chromatography (0-50% EtOAc/Hex) to afford the desired product as a white solid. MS (m/z)=490 (M+H).

Provenance & Evidence