Sodium Iodide → HCID 136983916, compound

Participants

Reaction Steps

To (R)-tert-butyl 3-((5-fluoro-6′-methoxy-2′-morpholino-[2,5′-bipyrimidin]-4′-yl)amino)piperidine-1-carboxylate (0.025 g, 0.051 mmol) in MeCN (1 mL) was added NaI (0.011 g, 0.077 mmol) followed by TMS-Cl (9.79 μl, 0.077 mmol). The reaction was stirred at room temperature for 15 min. then heated to 50° C. for 3 h. The solvent was removed in vacuo and the residue was purified via semi-preparative HPLC to afford the desired product as a white solid. MS (m/z)=376 (M+H). IRAK4 IC50=220 nM

Provenance & Evidence