Diisopropylethylamine → HCID 136504501, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of benzyl 4-[5-(1,3-benzothiazol-2-yl)-4-chloro-6-hydroxypyrimidin-2-yl]piperidine-1-carboxylate (48.1 mg, 0.10 mmol, 1.00 equiv), tert-butyl (3R)-3-aminopiperidine-1-carboxylate (20.1 mg, 0.10 mmol, 1.00 equiv), and N-ethyl-N-isopropylpropan-2-amine (25.4 mg, 0.20 mmol, 1.97 equiv) in ethanol (3 ml) was heated overnight at 90° C. in an oil bath. Upon concentrated under vacuum, the residue was purified by flash chromatography on a silica gel column eluting with petroleum ether/ethyl acetate (1:1) to afford the title compound. as a yellow solid. MS m/z [M+H]+ (ESI): 645.

Provenance & Evidence