1,3-Dioxolane-4-methanamine, 2,2-dimethyl- → HCID 117677719, compound

Participants

Reaction Conditions

Reaction Steps

Into a solution of 2-[4,6-dichloro-2-(morpholin-4-yl)pyrimidin-5-yl]-1,3-benzothiazole (200 mg, 0.54 mmol, 1.00 equiv) in ethanol (3 mL) was added (2,2-dimethyl-1,3-dioxolan-4-yl)methylamine (142.9 mg, 1.09 mmol, 2.00 equiv). The resulting solution was stirred for 3 h at 85° C. Removal of the solvent under reducing pressure gave 0.35 g (crude) of the title compound as a yellow solid, which was used for next step without further purification. MS m/z [M+H]+ (ESI): 462.

Provenance & Evidence