Methanol → 2H-Pyran-4-carboxylic acid, tetrahydro-, methyl ester

Participants

Reaction Steps

Into a solution of oxane-4-carboxylic acid (50 mg, 0.38 mmol, 1.00 equiv) in methanol (10 mL) was added thionyl chloride (46 mg, 0.39 mmol, 1.01 equiv) dropwise with stirring at room temperature. The resulting solution was stirred for 3 h at room temperature. Concentration under reducing pressure gave the title compound, which was used directly for next step without further purification (brown oil).

Provenance & Evidence