Hydrochloric Acid → 5-(trifluoromethyl)-1,3-benzothiazole-2-thiol

Participants

Reaction Conditions

Reaction Steps

Into a solution of 2-bromo-5-(trifluoromethyl)aniline (1.5 g, 6.25 mmol, 1.00 equiv) in N,N-dimethylformamide (10.0 mL) was added ethoxy(potassiosulfanyl)methanethione (2.2 g, 13.72 mmol, 2.20 equiv) under nitrogen. The resulting mixture was heated for 4 h at 120° C. in an oil bath. After cooled down, water (70.0 mL) and hydrogen chloride (15.0 mL, 1 mol/L) were added. The solid was collected by filtration, dissolved in ethyl acetate and dried over anhydrous sodium sulfate. Filtration and evaporation of the solvent afforded the title compound. as a gray white solid. MS m/z [M+H]+ (ESI): 236

Provenance & Evidence