Cesium carbonate → Tert-butyl 3-(6-methoxy-5-(7-methylbenzo[d]thiazol-2-yl)-2-morpholino-1,6-dihydropyrimidin-4-ylamino)piperidine-1-carboxylate

Participants

Reaction Steps

Following the same procedure as in step 3 of Example 337 using tert-butyl (3R)-3-[[5-iodo-6-methoxy-2-(morpholin-4-yl)-1,6-dihydropyrimidin-4-yl]amino]piperidine-1-carboxylate (30 mg, 0.06 mmol, 1.00 equiv), 7-methyl-1,3-benzothiazole (15.5 mg, 0.10 mmol, 1.81 equiv), tetrakis(triphenylphosphane) palladium (12 mg, 0.01 mmol, 0.18 equiv), iodocopper (2 mg, 0.01 mmol, 0.18 equiv), and cesium Carbonate (112.8 mg, 0.35 mmol, 6.00 equiv) in N,N-dimethylformamide (2.5 mL). The crude product was purified through a silica gel column with ethyl acetate/petroleum ether (1:10-1:5) to afford the title compound as a brown solid.

Provenance & Evidence