反应详情

Following the same procedure as in step 3 of Example 337 using 5-chloro-1,3-benzothiazole (59.4 mg, 0.35 mmol), tert-butyl (3R)-3-[[5-iodo-6-methoxy-2-(morpholin-4-yl)pyrimidin-4-yl]amino]piperidine-1-carboxylate (100 mg, 0.19 mmol), cesium carbonate (0.37 mg), tetrakis(triphenylphosphine)palladium (40.4 mg, 0.03 mmol, 0.18 equiv) and copper (I) iodide (6.7 mg, 0.04 mmol) in DMF (5.0 mL). The crude product was purified by chromatography on a silica gel column with ethyl acetate/petroleum ether (1:10-1:3) to afford the title compound as a light yellow solid.

1. customThe crude product was purified by chromatography on a silica gel column with ethyl acetate/petroleum ether (1:10-1:3)