Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1507553Generated: October 29, 2026

HCID 13589228, compound → HCID 90047529, compound

https://huagongshe.com/reaction/1507553

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 13589228HCID 13589228—
Reactant6-Amino-1,3,3-trimethyl-1,3-dihydro-2H-indol-2-oneHCID 52911248—
ReactantHCID 118415187HCID 118415187—
ProductHCID 90047529HCID 90047529—

Reaction Steps

Prepared in analogy to example 2 using 6′-amino-1′-methyl-spiro[cyclopentane-1,3′-indoline]-2′-one (prepared in analogy to procedures described in W. von der Saal et al., J. Med. Chem. 1989, 32(7), 1481-1491 for the preparation of 6-amino-1,3,3-trimethylindolin-2-one by methylation and nitro reduction of 6′-nitro-spiro[cyclopentane-1,3′-indolin]-2′-one (A. Mertens et al. J. Med. Chem. 1987, 30 (8), 1279-1287)). The title compound was obtained as light yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09221816B2
Source datasetuspto-grants-2015_12
ORD IDord-e1278e2778d54d0589892ae33399a5a8
Source noteuspto-grants-2015_12