HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 13589228, compound → HCID 90047529, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 13589228 | HCID 13589228 | — |
| Reactant | 6-Amino-1,3,3-trimethyl-1,3-dihydro-2H-indol-2-one | HCID 52911248 | — |
| Reactant | HCID 118415187 | HCID 118415187 | — |
| Product | HCID 90047529 | HCID 90047529 | — |
Reaction Steps
Prepared in analogy to example 2 using 6′-amino-1′-methyl-spiro[cyclopentane-1,3′-indoline]-2′-one (prepared in analogy to procedures described in W. von der Saal et al., J. Med. Chem. 1989, 32(7), 1481-1491 for the preparation of 6-amino-1,3,3-trimethylindolin-2-one by methylation and nitro reduction of 6′-nitro-spiro[cyclopentane-1,3′-indolin]-2′-one (A. Mertens et al. J. Med. Chem. 1987, 30 (8), 1279-1287)). The title compound was obtained as light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221816B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-e1278e2778d54d0589892ae33399a5a8 |
| Source note | uspto-grants-2015_12 |