Nicotinic Acid → HCID 73425723, compound

HRID 1507566Notes

Reaction equation

HRID 1507566 reaction equation
[NH2:1][C:2]1[C:10]([F:11])=[C:9]2[C:5]([C:6]([CH3:15])([CH3:14])[C:7](=[O:13])[N:8]2[CH3:12])=[CH:4][CH:3]=1.[C:16](O)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[N:19][CH:18]=1>>[F:11][C:10]1[C:2]([NH:1][C:16](=[O:23])[C:17]2[CH:22]=[CH:21][CH:20]=[N:19][CH:18]=2)=[CH:3][CH:4]=[C:5]2[C:9]=1[N:8]([CH3:12])[C:7](=[O:13])[C:6]2([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 90047452HCID 90047452, compound

Product 1

HCID 73425723HCID 73425723, compound

Procedure

Prepared in analogy to example 26 from 6-amino-7-fluoro-1,3,3-trimethylindolin-2-one (example 13d) and nicotinic acid. The title compound was obtained as off-white crystals.

Sources & evidence

ORD record
ord-292f93b0e9c649cb88e08164687c15b0
Source dataset
uspto-grants-2015_12
Patent number
US09221816B2

Reaction notes

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