Nicotinic Acid → HCID 73425724, compound

HRID 1507567Notes

Reaction equation

HRID 1507567 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:14])([CH3:13])[C:7](=[O:12])[N:8]2[CH3:11])=[CH:4][C:3]=1[F:15].[C:16](O)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[N:19][CH:18]=1>>[F:15][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:2]=1[NH:1][C:16](=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[N:19][CH:18]=1)[N:8]([CH3:11])[C:7](=[O:12])[C:6]2([CH3:13])[CH3:14]

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 90047514HCID 90047514, compound

Product 1

HCID 73425724HCID 73425724, compound

Procedure

Prepared in analogy to example 17 from 6-amino-5-fluoro-1,3,3-trimethylindolin-2-one (example 20 f) and nicotinic acid. The title compound was obtained as off-white solid.

Sources & evidence

ORD record
ord-0df02ec70a1f47f688eb006409fdd132
Source dataset
uspto-grants-2015_12
Patent number
US09221816B2

Reaction notes

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