2-Methylpyridine-4-carboxylic acid → HCID 73425826, compound

HRID 1507571Notes

Reaction equation

HRID 1507571 reaction equation
[NH2:1][C:2]1[C:10]([F:11])=[C:9]2[C:5]([C:6]([CH3:15])([CH3:14])[C:7](=[O:13])[N:8]2[CH3:12])=[CH:4][CH:3]=1.[CH3:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][N:25]=1)[C:20](O)=[O:21]>>[F:11][C:10]1[C:2]([NH:1][C:20](=[O:21])[C:19]2[CH:23]=[CH:24][N:25]=[C:17]([CH3:16])[CH:18]=2)=[CH:3][CH:4]=[C:5]2[C:9]=1[N:8]([CH3:12])[C:7](=[O:13])[C:6]2([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 27628212-Methylpyridine-4-carboxylic acidHCID 90047452HCID 90047452, compound

Product 1

HCID 73425826HCID 73425826, compound

Procedure

Prepared in analogy to example 26 from 6-amino-7-fluoro-1,3,3-trimethylindolin-2-one (example 13d) and 2-methylisonicotinic acid. The title compound was obtained as light yellow crystals.

Sources & evidence

ORD record
ord-826dc4654197401eb3421a3689c73952
Source dataset
uspto-grants-2015_12
Patent number
US09221816B2

Reaction notes

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