3-Fluoropyridine-4-carboxylic acid → HCID 73425828, compound

HRID 1507573Notes

Reaction equation

HRID 1507573 reaction equation
[F:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:11][C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH3:26])([CH3:25])[C:17](=[O:24])[N:18]2[CH:21]2[CH2:23][CH2:22]2)=[CH:14][CH:13]=1>>[CH:21]1([N:18]2[C:19]3[C:15](=[CH:14][CH:13]=[C:12]([NH:11][C:4](=[O:6])[C:3]4[CH:7]=[CH:8][N:9]=[CH:10][C:2]=4[F:1])[CH:20]=3)[C:16]([CH3:25])([CH3:26])[C:17]2=[O:24])[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 3453613-Fluoropyridine-4-carboxylic acidHCID 1184151856-Amino-1-cyclopropyl-3,3-dimethyl-1,3-dihydro-indol-2-one

Product 1

HCID 73425828HCID 73425828, compound

Procedure

Prepared in analogy to example 26 from 3-fluoroisonicotinic acid and 6-amino-1-cyclopropyl-3,3-dimethyl-1,3-dihydro-indol-2-one (example 14c). The title compound was obtained as light yellow solid.

Sources & evidence

ORD record
ord-7c654f0d219945048fecaaaba1274215
Source dataset
uspto-grants-2015_12
Patent number
US09221816B2

Reaction notes

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