6-Methylnicotinic acid → HCID 73425829, compound

HRID 1507574Notes

Reaction equation

HRID 1507574 reaction equation
[NH2:1][C:2]1[C:10]([F:11])=[C:9]2[C:5]([C:6]([CH3:15])([CH3:14])[C:7](=[O:13])[N:8]2[CH3:12])=[CH:4][CH:3]=1.[CH3:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](O)=[O:22])=[CH:19][N:18]=1>>[F:11][C:10]1[C:2]([NH:1][C:21](=[O:22])[C:20]2[CH:24]=[CH:25][C:17]([CH3:16])=[N:18][CH:19]=2)=[CH:3][CH:4]=[C:5]2[C:9]=1[N:8]([CH3:12])[C:7](=[O:13])[C:6]2([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 1378606-Methylnicotinic acidHCID 90047452HCID 90047452, compound

Product 1

HCID 73425829HCID 73425829, compound

Procedure

Prepared in analogy to example 1b from 6-amino-7-fluoro-1,3,3-trimethylindolin-2-one (example 13d) and 6-methylnicotinic acid. The title compound was obtained as dark red foam.

Sources & evidence

ORD record
ord-47745299bdb04c199e92b163863ef655
Source dataset
uspto-grants-2015_12
Patent number
US09221816B2

Reaction notes

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