Nicotinic Acid → N-(1-Isopropyl-3,3-dimethyl-2-oxoindolin-6-yl)nicotinamide

HRID 1507578Notes

Reaction equation

[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:16])([CH3:15])[C:7](=[O:14])[N:8]2[CH:11]([CH3:13])[CH3:12])=[CH:4][CH:3]=1.[C:17](O)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[N:20][CH:19]=1>>[CH:11]([N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([NH:1][C:17](=[O:24])[C:18]3[CH:23]=[CH:22][CH:21]=[N:20][CH:19]=3)[CH:10]=2)[C:6]([CH3:16])([CH3:15])[C:7]1=[O:14])([CH3:12])[CH3:13]

Participants

Reactant 2

HCID 938Nicotinic Acid

HCID 900464376-Amino-1-isopropyl-3,3-dimethyl-1,3-dihydro-indol-2-one

Product 1

HCID 73425944N-(1-Isopropyl-3,3-dimethyl-2-oxoindolin-6-yl)nicotinamide

Procedure

Prepared in analogy to example 26 from 6-amino-1-isopropyl-3,3-dimethyl-1,3-dihydro-indol-2-one and nicotinic acid. The title compound was obtained as white foam.

Sources & evidence

ORD record: ord-dd164edf674849bfb94aa1486f0e060b
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09221816B2

Reaction notes

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