3-Fluoropyridine-4-carboxylic acid → N-(1-ethyl-3,3-dimethyl-2-oxoindolin-6-yl)-3-fluoroisonicotinamide

HRID 1507580Notes

Reaction equation

HRID 1507580 reaction equation
[F:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:11][C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH3:25])([CH3:24])[C:17](=[O:23])[N:18]2[CH2:21][CH3:22])=[CH:14][CH:13]=1>>[CH2:21]([N:18]1[C:19]2[C:15](=[CH:14][CH:13]=[C:12]([NH:11][C:4](=[O:6])[C:3]3[CH:7]=[CH:8][N:9]=[CH:10][C:2]=3[F:1])[CH:20]=2)[C:16]([CH3:25])([CH3:24])[C:17]1=[O:23])[CH3:22]

Participants

3

Reactant 2

HCID 3453613-Fluoropyridine-4-carboxylic acidHCID 69068988HCID 69068988, compound2×

Product 1

HCID 73425948N-(1-ethyl-3,3-dimethyl-2-oxoindolin-6-yl)-3-fluoroisonicotinamide

Procedure

Prepared in analogy to example 26 from 3-fluoroisonicotinic acid and 6-amino-1-ethyl-3,3-dimethylindolin-2-one (G. Georges et al., US2006/142247 A1). The title compound was obtained as light yellow solid.

Sources & evidence

ORD record
ord-927aadaa1c3b4711a372aedc4594afc5
Source dataset
uspto-grants-2015_12
Patent number
US09221816B2

Reaction notes

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