2-Methylpyridine-4-carboxylic acid → HCID 73426059, compound

HRID 1507583Notes

Reaction equation

HRID 1507583 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:16])([CH3:15])[C:7](=[O:14])[N:8]2[CH:11]2[CH2:13][CH2:12]2)=[CH:4][C:3]=1[F:17].[CH3:18][C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][N:27]=1)[C:22](O)=[O:23]>>[CH:11]1([N:8]2[C:9]3[C:5](=[CH:4][C:3]([F:17])=[C:2]([NH:1][C:22](=[O:23])[C:21]4[CH:25]=[CH:26][N:27]=[C:19]([CH3:18])[CH:20]=4)[CH:10]=3)[C:6]([CH3:15])([CH3:16])[C:7]2=[O:14])[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 27628212-Methylpyridine-4-carboxylic acidHCID 90046309HCID 90046309, compound

Product 1

HCID 73426059HCID 73426059, compound

Procedure

Prepared in analogy to example 26 from 6-amino-1-cyclopropyl-5-fluoro-3,3-dimethyl-1,3-dihydro-indol-2-one and 2-methylisonicotinic acid. The title compound was obtained as light yellow crystals.

Sources & evidence

ORD record
ord-7d815e663b2b400fb2f1d385e446c4be
Source dataset
uspto-grants-2015_12
Patent number
US09221816B2

Reaction notes

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