3-Fluoropyridine-4-carboxylic acid → HCID 73426061, compound

HRID 1507585Notes

Reaction equation

HRID 1507585 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:14])([CH3:13])[C:7](=[O:12])[N:8]2[CH3:11])=[CH:4][C:3]=1[F:15].[F:16][C:17]1[CH:25]=[N:24][CH:23]=[CH:22][C:18]=1[C:19](O)=[O:20]>>[F:16][C:17]1[CH:25]=[N:24][CH:23]=[CH:22][C:18]=1[C:19]([NH:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:13])([CH3:14])[C:7](=[O:12])[N:8]2[CH3:11])=[CH:4][C:3]=1[F:15])=[O:20]

Participants

3

Reactant 2

HCID 3453613-Fluoropyridine-4-carboxylic acidHCID 90047514HCID 90047514, compound

Product 1

HCID 73426061HCID 73426061, compound

Procedure

Prepared in analogy to example 26 from 6-amino-5-fluoro-1,3,3-trimethylindolin-2-one (example 20 f) and 3-fluoroisonicotinic acid. The title compound was obtained as light yellow crystals.

Sources & evidence

ORD record
ord-ac4ad5ab17b44e8c9c656b49ff07ac42
Source dataset
uspto-grants-2015_12
Patent number
US09221816B2

Reaction notes

Loading…