HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoro-2-methylisonicotinic acid → N-(1-Cyclopropyl-3,3-dimethyl-2-oxoindolin-6-yl)-5-fluoro-2-methylisonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoro-2-methylisonicotinic acid | HCID 57649620 | — |
| Reactant | 6-Amino-1-cyclopropyl-3,3-dimethyl-1,3-dihydro-indol-2-one | HCID 118415185 | — |
| Product | N-(1-Cyclopropyl-3,3-dimethyl-2-oxoindolin-6-yl)-5-fluoro-2-methylisonicotinamide | HCID 73426162 | — |
Reaction Steps
Prepared in analogy to example 26 from 6-amino-1-cyclopropyl-3,3-dimethyl-1,3-dihydro-indol-2-one (example 14c) and 5-fluoro-2-methyl-isonicotinic acid (prepared according to U. Abel et al., WO200645514). The title compound was obtained as light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221816B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-21e01faa3a774c1a941814ac602e8f41 |
| Source note | uspto-grants-2015_12 |