Hydrochloric Acid → HCID 90047521, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-(benzylamino)-1,3,3-trimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (610 mg, 2.17 mmol) and 25% aqueous HCl solution (1.2 g, 1 ml, 8.23 mmol) in ethanol (20 ml) was evacuated three times and flushed with argon. Pd (10% on activated charcoal, 231 mg, 217 μmol) was added. Degassing was repeated, then evacuated three times and flushed with hydrogen. The reaction mixture was heated to 40° C. and stirred 4 hours at this temperature under the hydrogen atmosphere. The reaction mixture was filtered through a glass fiber filter, washed with EtOH and the solvent was evaporated. The title compound was obtained as grey solid (388 mg) and was used without further purification.

Provenance & Evidence