2-Methylpyridine-4-carboxylic acid → N-(1-Cyclopropyl-3,3-dimethyl-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6-yl)-2-methylisonicotinamide

HRID 1507607Notes

Reaction equation

HRID 1507607 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([OH:7])=O.[NH2:11][C:12]1[N:17]=[CH:16][C:15]2[C:18]([CH3:26])([CH3:25])[C:19](=[O:24])[N:20]([CH:21]3[CH2:23][CH2:22]3)[C:14]=2[CH:13]=1>>[CH:21]1([N:20]2[C:14]3[CH:13]=[C:12]([NH:11][C:5](=[O:7])[C:4]4[CH:8]=[CH:9][N:10]=[C:2]([CH3:1])[CH:3]=4)[N:17]=[CH:16][C:15]=3[C:18]([CH3:25])([CH3:26])[C:19]2=[O:24])[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 27628212-Methylpyridine-4-carboxylic acidHCID 900475166-Amino-1-cyclopropyl-3,3-dimethyl-1H-pyrrolo[3,2-c]pyridin-2(3H)-one

Product 1

HCID 73426650N-(1-Cyclopropyl-3,3-dimethyl-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6-yl)-2-methylisonicotinamide

Procedure

Prepared in analogy to example 26 from 2-methylisonicotinic acid and 6-amino-1-cyclopropyl-3,3-dimethyl-1H-pyrrolo[3,2-c]pyridin-2(3H)-one (example 79c). The title compound was obtained as off-white foam.

Sources & evidence

ORD record
ord-31c136c384de486e89558b4215b55bb1
Source dataset
uspto-grants-2015_12
Patent number
US09221816B2

Reaction notes

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