1,2-Oxazole-5-carboxylic acid → N-(1-Cyclopropyl-3,3-dimethyl-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6-yl)isoxazole-5-carboxamide

HRID 1507611Notes

Reaction equation

HRID 1507611 reaction equation
[O:1]1[C:5]([C:6]([OH:8])=O)=[CH:4][CH:3]=[N:2]1.[NH2:9][C:10]1[N:15]=[CH:14][C:13]2[C:16]([CH3:24])([CH3:23])[C:17](=[O:22])[N:18]([CH:19]3[CH2:21][CH2:20]3)[C:12]=2[CH:11]=1>>[CH:19]1([N:18]2[C:12]3[CH:11]=[C:10]([NH:9][C:6]([C:5]4[O:1][N:2]=[CH:3][CH:4]=4)=[O:8])[N:15]=[CH:14][C:13]=3[C:16]([CH3:23])([CH3:24])[C:17]2=[O:22])[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 20605991,2-Oxazole-5-carboxylic acidHCID 900475166-Amino-1-cyclopropyl-3,3-dimethyl-1H-pyrrolo[3,2-c]pyridin-2(3H)-one

Product 1

HCID 73426547N-(1-Cyclopropyl-3,3-dimethyl-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6-yl)isoxazole-5-carboxamide

Procedure

Prepared in analogy to example 26 from isoxazole-5-carboxylic acid and 6-amino-1-cyclopropyl-3,3-dimethyl-1H-pyrrolo[3,2-c]pyridin-2(3H)-one (example 79c). The title compound was obtained as light yellow solid.

Sources & evidence

ORD record
ord-6e687ebf24b74da3b68d35b83eb66e84
Source dataset
uspto-grants-2015_12
Patent number
US09221816B2

Reaction notes

Loading…