1-methyl-1H-pyrazole-3-carboxylic acid → N-(1-Cyclopropyl-3,3-dimethyl-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6-yl)-1-methyl-1H-pyrazole-3-carboxamide

HRID 1507613Notes

Reaction equation

HRID 1507613 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([C:7]([OH:9])=O)=[N:3]1.[NH2:10][C:11]1[N:16]=[CH:15][C:14]2[C:17]([CH3:25])([CH3:24])[C:18](=[O:23])[N:19]([CH:20]3[CH2:22][CH2:21]3)[C:13]=2[CH:12]=1>>[CH:20]1([N:19]2[C:13]3[CH:12]=[C:11]([NH:10][C:7]([C:4]4[CH:5]=[CH:6][N:2]([CH3:1])[N:3]=4)=[O:9])[N:16]=[CH:15][C:14]=3[C:17]([CH3:24])([CH3:25])[C:18]2=[O:23])[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 5731761-methyl-1H-pyrazole-3-carboxylic acidHCID 900475166-Amino-1-cyclopropyl-3,3-dimethyl-1H-pyrrolo[3,2-c]pyridin-2(3H)-one

Product 1

HCID 73426549N-(1-Cyclopropyl-3,3-dimethyl-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6-yl)-1-methyl-1H-pyrazole-3-carboxamide

Procedure

Prepared in analogy to example 26 from 1-methyl-1H-pyrazole-3-carboxylic acid and 6-amino-1-cyclopropyl-3,3-dimethyl-1H-pyrrolo[3,2-c]pyridin-2(3H)-one (example 79c). The title compound was obtained as white crystals.

Sources & evidence

ORD record
ord-67f429a4e00a4d539443e4dbf773f72e
Source dataset
uspto-grants-2015_12
Patent number
US09221816B2

Reaction notes

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