Sodium Dithionite → HCID 57883120, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-Chloro-N-(1-cyclopropyl-5-nitroso-2,6-dioxo-3-propyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-nicotinamide (8.2 g, 21.71 mmol, 1 eq) in 60 ml of DMSO was added Na2S2O4 (15.11 g, 86.84 mmol, 4 eq). The mixture was stirred at 90° C. for 3 hours. The mixture was quenched with water (50 ml). The resulting precipitate was obtained by filtration and washed with water to give the desired product (5.78 g, 77%) after vacuum dried overnight at 40° C.: 1H NMR (400 MHz, DMSO-d6) δ 14.1 (1H), 9.08 (1H), 8.48 (1H), 7.7 (1H), 4.00 (2H), 2.62 (1H), 1.78 (2H), 1.14 (2H), 0.92 (3H), 0.75 (2H); m/z (ES+) 346.79

Provenance & Evidence