反应详情

To a solution of 6-Amino-3-cyclopropyl-1H-pyrimidine-2,4-dione (5.0 g, 29.9 mmol, 1 eq) in 50% aq AcOH (10 ml) was added NaNO2 (4.13 g, 59.8 mmol, 2 eq) in small portions over a period of 10 min. The mixture was stirred for 1 hr. The purple precipitate was collected by filtration and washed with cold water to give 4.75 g, 81%, m/z (ES+) 197.17), which was used in the following step.

1. filtrationThe purple precipitate was collected by filtration
2. washwashed with cold water
3. customto give 4.75 g, 81%, m/z (ES+) 197.17), which