Sodium Nitrite → HCID 86704349, compound

HRID 1507621Notes

Reaction equation

HRID 1507621 reaction equation
[NH2:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH:9]2[CH2:11][CH2:10]2)[C:4](=[O:12])[CH:3]=1.[N:13]([O-])=[O:14].[Na+]>CC(O)=O>[NH2:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH:9]2[CH2:10][CH2:11]2)[C:4](=[O:12])[C:3]=1[N:13]=[O:14]

Participants

4

Reactant 2

HCID 23668193Sodium NitriteHCID 867043506-Amino-3-cyclopropyl-1H-pyrimidine-2,4-dione

Product 1

HCID 86704349HCID 86704349, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of 6-Amino-3-cyclopropyl-1H-pyrimidine-2,4-dione (5.0 g, 29.9 mmol, 1 eq) in 50% aq AcOH (10 ml) was added NaNO2 (4.13 g, 59.8 mmol, 2 eq) in small portions over a period of 10 min. The mixture was stirred for 1 hr. The purple precipitate was collected by filtration and washed with cold water to give 4.75 g, 81%, m/z (ES+) 197.17), which was used in the following step.

Workup

  1. filtrationThe purple precipitate was collected by filtration
  2. washwashed with cold water
  3. customto give 4.75 g, 81%, m/z (ES+) 197.17), which

Sources & evidence

ORD record
ord-7e0ee149aa05484eb74c8cc14d5302fa
Source dataset
uspto-grants-2015_12
Patent number
US09221821B2

Reaction notes

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