関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Ethyl bromoacetate | HCID 7748 | — |
| 反応物 | 4-Fluoroaniline | HCID 9731 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 生成物 | ethyl N-(4-fluorophenyl)glycine | HCID 61998283 | — |
反応手順
Using the procedure described in WO 9857937 A2, to a solution of 13.56 g (122 mmole) p-fluoroaniline in DMF (100 mL) under nitrogen was added 23.5 g (141 mmol) of ethyl bromoacetate and 14.95 g (141 mmol) anhydrous sodium carbonate. The mixture was heated to 70° C. for 16 h and then cooled to room temperature. Water was added (500 mL) and the mixture stirred vigorously until a precipitate formed. The solid was filtered, washed with 100 mL water and dried to afford ethyl N-(4-fluorophenyl)glycine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09221805B2 |
|---|
| 出典データセット | uspto-grants-2015_12 |
|---|
| ORD ID | ord-e85fbe1affef462ab50755d2d5a46483 |
|---|
| 出典メモ | uspto-grants-2015_12 |
|---|
