(4-Fluoroanilino)acetic acid → N-(4-fluorophenyl)-N-nitrosoglycine

Beteiligte Stoffe

Reaktionsschritte

Sodium nitrite (3.97 g), 57.5 mmol) in 10 mL water was added to a suspension of N-(4-fluorophenyl)glycine 9.25 g (54.7 mmol) in water (50 mL) under nitrogen. The reaction mixture was stirred until clear, ca. 6 hours. Acidification to pH 3 with HCl precipitated the product which was filtered and washed with water (50 mL) and dried to afford the title product.

Herkunft & Nachweise