反应详情

2-Chloro-5-nitro-benzoic acid methyl ester 15 (4.3 g, 20.2 mmol), SnCl2-2H2O (45.5 g, 201.8 mmol) and ethanol (100 mL) were combined into a sealed pressure vial and was sonicated for 2 hr. The solvent was concentrated and the residue was dissolved in EtOAc, washed with NaHCO3, brine, dried over MgSO4 and filtered. The solvent was evaporated to give the desired product 16 (2.8 g, 73%).

1. customwas sonicated for 2 hr
2. concentrationThe solvent was concentrated
3. dissolutionthe residue was dissolved in EtOAc
4. washwashed with NaHCO3, brine
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customThe solvent was evaporated