HCID 1277656, compound → tert-Butyl (5-amino-2-methylphenyl)carbamate

HRID 1507641Notes

Reaction equation

HRID 1507641 reaction equation
[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[C:12]([N+:14]([O-])=O)[CH:11]=[CH:10][C:9]=1[CH3:17])([CH3:4])([CH3:3])[CH3:2]>C(O)C>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[C:12]([NH2:14])[CH:11]=[CH:10][C:9]=1[CH3:17])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 1277656HCID 1277656, compound

Product 1

HCID 10799065tert-Butyl (5-amino-2-methylphenyl)carbamateYield 113.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(2-Methyl-5-nitro-phenyl)-carbamic acid tert-butyl ester 21 (4.5 g, 17.8 mmol) was dissolved in ethanol (100 mL) and Pd-c (5%, 100 mg) was added and the mixture was stirred under H2(g) at 50 PSI on a Parr shaker overnight. The mixture was filtered through celite and the solvent was evaporated to give the desired product 22 (4.5 g, quantitative yield).

Workup

  1. filtrationThe mixture was filtered through celite
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-08511a2dabb04059bec988cc92fb561a
Source dataset
uspto-grants-2015_12
Patent number
US09221805B2

Reaction notes

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