1,4-Dioxane → HCID 89610490, compound

Participants

Reaction Steps

Diethyl 3-(benzyloxy)-4-(2-(tert-butoxy)-2-oxoethoxy)-1-(4-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylate (UL2-028) (250 mg, 0.45 mmol) was dissolved in 4 M HCl in dioxane (2.5 mL, 10.0 mmol), and the reaction mixture was stirred at RT for 2 h, volatiles were removed in vacuo and the product was azeotroped with toluene (2×5 mL) to afford 2-((4-(benzyloxy)-2,5-bis(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)oxy)acetic acid (24) (216 mg, 87%) as a yellow oil: m/z 498 (M+H)+ (ES+); 496 (M−H)− (ES−).

Provenance & Evidence