HCID 89610373, compound → HCID 89610495, compound

Participants

Reaction Steps

Diethyl 3-(2-amino-2-oxoethoxy)-4-(benzyloxy)-1-(4-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylate (25) (66 mg, 0.133 mmol) in MeOH (66 mL) was passed through a Thales ‘H-cube’ cartridge (10% Pd/C) at a flow rate of 1 mL/min at 20° C. under H2 (full H2 mode). The output was concentrated in vacuo to afford a yellow oil. The residue was purified by silica gel chromatography (4 g, 0-100% EtOAc in isohexane) to afford diethyl 3-(2-amino-2-oxoethoxy)-4-hydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylate (UL2-031) (25 mg, 46%) as a white solid: m/z 407 (M+H)+ (ES+); 405 (M−H)− (ES−). 1H NMR (400 MHz, DMSO-d6) δ: 9.61 (s, 1H), 7.82-7.63 (m, 2H), 7.10-7.06 (m, 2H), 6.93-6.84 (m, 2H), 4.49 (s, 2H), 4.03-3.93 (m, 4H), 3.79 (s, 3H), 1.05-0.94 (m, 6H).

Provenance & Evidence