HCID 89610295, compound → HCID 89610574, compound

Participants

Reaction Steps

A solution of ethyl 4-((bis(benzyloxy)phosphoryl)oxy)-5-(dimethylcarbamoyl)-3-hydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate (26) (225 mg, 0.37 mmol) in MeOH (10 mL) was passed through a Thales ‘H-cube’ cartridge (10% Pd/C) at a flow rate of 1 mL/min at 30° C. under H2 (full H2 mode). The output was concentrated in vacuo to afford ethyl 5-(dimethylcarbamoyl)-3-hydroxy-1-(4-methoxyphenyl)-4-(phosphonooxy)-1H-pyrrole-2-carboxylate (UL1-070) (151 mg, 94%) as a pale yellow solid: m/z 429 (M+H)+ (ES+); 427 (M−H)− (ES−), 1H NMR (400 MHz, DMSO-d6) δ: 7.11-7.03 (m, 2H), 6.93-6.85 (m, 2H), 3.99 (q, J=7.1 Hz, 2H), 3.77 (s, 3H), 2.82 (s, 3H), 2.71 (s, 3H), 1.02 (t, J=7.1 Hz, 3H).

Provenance & Evidence