HCID 117642516, compound → HCID 117642616, compound

Participants

Reaction Steps

A solution of 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-(3-((bis(benzyloxy)phosphoryl)oxy)propoxy)-2,2-dimethylpropanoate) (56) (37 mg, 0.03 mmol) in MeOH (4 mL) was passed through a Thales ‘H-cube’ cartridge (10% Pd/C) at a flow rate of 1 mL/min at 40° C. under H2 (full H2 mode). The output was concentrated in vacuo to afford 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2,2-dimethyl-3-(3-(phosphonooxy)propoxy)propanoate) (UL1-118) (25 mg, 95%) as a white gum: m/z 825 (M+H)+ (ES+); 823 (M−H)− (ES−). 1H NMR (400 MHz, DMSO-d6) δ: 7.24-7.16 (m, 2H), 6.98-6.91 (m, 2H), 4.01 (q, J=7.1 Hz, 2H), 3.90-3.81 (m, 4H), 3.79 (s, 3H), 3.51-3.43 (m, 8H), 2.82 (s, 3H), 2.70 (s, 3H), 1.86-1.73 (m, 4H), 1.25 (s, 6H), 1.19 (s, 6H), 1.01 (t, J=7.1 Hz, 3H).

Provenance & Evidence