HCID 117642836, compound → HCID 117642446, compound

Participants

Reaction Steps

A solution of 2,5-bis(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-(2-(2-((bis(benzyloxy)phosphoryl)oxy)ethoxy)ethoxy)-2,2-dimethylpropanoate) (62) (278 mg, 0.22 mmol) in MeOH (112 mL) was passed through a Thales ‘H-cube’ cartridge (10% Pd/C) at a flow rate of 1 mL/min at 45° C. under H2 (10 bar). The output was concentrated in vacuo to afford 2,5-bis(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2,2-dimethyl-3-(2-(2-(phosphonooxy)ethoxy)ethoxy)propanoate) (UL1-121) (175 mg, 88%) as a light yellow oil: m/z 884 (M+H)+ (ES+); 882 (M−H)− (ES−). 1H NMR (400 MHz, DMSO-d6) δ: 7.11-7.09 (m, 2H), 6.97-6.95 (m, 2H), 3.91-3.87 (m, 4H), 3.78 (s, 3H), 3.58-3.50 (m, 16H), 2.89 (s, 6H), 2.76 (s, 6H), 1.19 (s, 12H).

Provenance & Evidence