HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[(5-chloro-2-pyridinyl)methoxy]-1-(4-{2-[(3S)-3-hydroxy-1-pyrrolidinyl]ethoxy}phenyl)-1H-pyridin-2-one → 2-[(3R)-3-(2-fluoroethoxy)-1-pyrrolidinyl]ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[(5-chloro-2-pyridinyl)methoxy]-1-(4-{2-[(3S)-3-hydroxy-1-pyrrolidinyl]ethoxy}phenyl)-1H-pyridin-2-one | HCID 58964903 | — |
| Reactant | (S)-tert-Butyl 2-(fluoromethyl)pyrrolidine-1-carboxylate | HCID 86586409 | — |
| Reactant | tert-butyl (3R)-3-(2-fluoroethoxy)pyrrolidine-1-carboxylate | HCID 86614896 | — |
| Product | 2-[(3R)-3-(2-fluoroethoxy)-1-pyrrolidinyl]ethanol | HCID 86614897 | — |
Reaction Steps
Steps (2) and (3) of Example 89 were repeated except that tert-butyl (2S)-2-(fluoromethyl)pyrrolidine-1-carboxylate used in the Step (2) was replaced with tert-butyl (3R)-3-(2-fluoroethoxy)pyrrolidine-1-carboxylate, to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732456B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-d32f389d5b4544a1bce23de638792fbd |
| Source note | uspto-grants-2010_06 |