HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Tolyl isocyanate → 4-(5-Amino-2-(pyridin-3-yl)thiazolo[5,4-d]pyrimidin-7-yl)-n-m-tolylpiperazine-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Tolyl isocyanate | HCID 69303 | — |
| Reactant | 7-(Piperazin-1-yl)-2-(pyridin-3-yl)thiazolo[5,4-d]pyrimidin-5-amine | HCID 50942056 | — |
| Product | 4-(5-Amino-2-(pyridin-3-yl)thiazolo[5,4-d]pyrimidin-7-yl)-n-m-tolylpiperazine-1-carboxamide | HCID 56940883 | 42% |
Reaction Steps
This compound was prepared from 7-(piperazin-1-yl)-2-(pyridin-3-yl)thiazolo[5,4-d]pyrimidin-5-amine using 3-tolyl isocyanate in a yield of 42%, according to the procedure for the synthesis of example 42.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221822B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-2de40f05339048c7b0f2b5aa1bccce26 |
| Source note | uspto-grants-2015_12 |