3-(4-Fluorophenyl)propionic acid → 2-(4-Fluorophenethyl)-7-(piperazin-1-yl)thiazolo[5,4-d]pyrimidine

HRID 1507842Notes

Reaction equation

HRID 1507842 reaction equation
[NH2:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)=[N:4][CH:5]=[N:6][C:7]=1[SH:8].[F:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][CH2:30][C:31](O)=O)=[CH:25][CH:24]=1>>[F:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][CH2:30][C:31]2[S:8][C:7]3[N:6]=[CH:5][N:4]=[C:3]([N:9]4[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]4)[C:2]=3[N:1]=2)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 1363023-(4-Fluorophenyl)propionic acidHCID 178452266Tert-butyl 4-(5-amino-6-mercaptopyrimidin-4-yl)piperazine-1-carboxylate

Product 1

HCID 667589612-(4-Fluorophenethyl)-7-(piperazin-1-yl)thiazolo[5,4-d]pyrimidineYield 80%

Procedure

This compound was synthesized from tert-butyl 4-(5-amino-6-mercaptopyrimidin-4-yl)piperazine-1-carboxylate using 3-(4-fluorophenyl)propionic acid, yielding the title compound in 80% yield.

Sources & evidence

ORD record
ord-2b0d1380166846b78e69e8df2ef99272
Source dataset
uspto-grants-2015_12
Patent number
US09221822B2

Reaction notes

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