Triethylamine → HCID 66547153, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (R)-6-(3-(aminomethyl)phenyl)-4-(3-fluoro-3-methylbutan-2-ylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide (Example 68, 18.5 mg, 0.050 mmol), 1,1′-carbonyldiimidazole (16.24 mg, 0.100 mmol), and Et3N (0.017 mL, 0.125 mmol) in C1CH2CH2Cl (1 mL) was stirred at 23° C. for 1 hr then cyclopropanamine (8.67 μl, 0.125 mmol) was added and the resulting mixture was heated to 80° C. for 30 minutes. The reaction was cooled, concentrated and redissolved in 1 mL of MeOH with a few drops of DMF. The reaction mixture was purified by reverse-phase preparative HPLC (condition C) to yield the title compound (14.2 mg, 61%). HPLC (condition H): retention time=1.42 minute. LC/MS (M+H)+=453.4.

Provenance & Evidence