HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyrrolidone → (R)-4-(1-cyclopropylethylamino)-6-(2-oxopyrrolidin-1-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyrrolidone | HCID 12025 | — |
| Reactant | (R)-6-bromo-4-(1-cyclopropylethylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide | HCID 68291753 | — |
| Product | (R)-4-(1-cyclopropylethylamino)-6-(2-oxopyrrolidin-1-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide | HCID 68292289 | — |
Reaction Steps
Example 185 was prepared from 6-bromo-4-(((1R)-1-cyclopropylethyl)amino)-pyrrolo[1,2-b]pyridazine-3-carboxamide (Intermediate 4) and 2-pyrrolidinone according to the procedure described for Example 37. HPLC (condition G): retention time=7.10 min. LCMS (ES+) m/z: 328.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221826B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-a54a958ae632483b867b5305c5c3b142 |
| Source note | uspto-grants-2015_12 |