Hydrochloric Acid → HCID 86706850, compound

Participants

Reaction Steps

HCl (4M in 1,4-dioxane) (15 mL, 60.0 mmol) was added in one portion to a solution of tert-butyl (2R)-1-cyclopropyl-1-hydroxypropan-2-ylcarbamate (745 mg, 3.46 mmol) in DCM (Volume: 10 mL). The reaction mixture was then allowed to stir at rt for 4 hrs before evaporating in vacuo. to give (2R)-2-amino-1-cyclopropylpropan-1-ol hydrochloride (525 mg, 3.46 mmol, 100% yield). 1H NMR (500 MHz, CD3OD) δ 3.78-3.72 (m, 1H), 3.25 (t, J=7.1 Hz, 3H), 3.05 (dd, J=8.3, 3.6 Hz, 1H), 2.87 (t, J=7.8 Hz, 2H), 1.39-1.32 (m, 3H), 0.89 (qt, J=8.1, 5.0 Hz, 1H), 0.67-0.51 (m, 2H), 0.46-0.32 (m, 2H).

Provenance & Evidence