Hydrochloric Acid → HCID 68291759, compound

Participants

Reaction Steps

A solution of tert-butyl((2R,3R)-3-(4-carbamoyloxazol-2-yl)pentan-2-yl)carbamate (677 mg, 2.28 mmol) in anhydrous dichloromethane (6 mL) was treated with HCl (4M HCl in 1,4-dioxane, 12 mL, 48.0 mmol) and allowed to stir at room temperature overnight. The reaction was then evaporated in vacuo to give 2-((2R,3R)-2-aminopentan-3-yl)oxazole-4-carboxamide hydrochloride (532 mg, 2.28 mmol, 100% yield) which was used immediately in the next reaction.

Provenance & Evidence