HuagongsheHuagongshe Chemistry Print Report · For research reference only
Naltrexone Base → Benzyl Alcohol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Naltrexone Base | HCID 21159611 | — |
| Solvent | Benzyl Alcohol | HCID 244 | — |
| Product | Benzyl Alcohol | HCID 244 | 70% |
| Product | 3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one | HCID 4428 | 30% |
Reaction Steps
A 1 kg batch of naltrexone microspheres were prepared as follows. Polymer solution was formed by dissolving 75:25 DL PLGA (poly(lactide)-co-glycolide) in ethyl acetate (EtAc) to form a solution of 16.7% polymer and 83.3% EtAc. A naltrexone solution was formed by dissolving naltrexone base in benzyl alcohol (BA) to form a solution of 30% naltrexone base anhydrous and 70% BA. The polymer solution and the naltrexone solution were mixed together to form a drug/polymer solution that was the “organic” or “oil” phase of the emulsion.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221830B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-17e634018c2144318a8ecbaf518c7585 |
| Source note | uspto-grants-2015_12 |